Prostacyclin ( Prostaglandin 12 , PGI 2 ) Inhibits Platelet Adhesion and Thrombus Formation on
نویسنده
چکیده
Prostaglandin I2 (prostacyclin, PGI2), a subadhesion and thrombus formation on subenstance synthesized in the wall of blood dothelium was inhibited in blood containing vessels, has been previously shown to inhibit 10 nM PGI2. PGI2 appears to reduce adhesion the aggregation of platelets in Stirred plateby inhibiting platelet spreading. These findlet-rich plasma. We used a method in which ings suggest that PGI2 could regulate the segments of deendothelialized rabbit aorta deposition of platelets on vascular surare perfused at arterial shear rates with faces. human blood and found that both platelet
منابع مشابه
Prostacyclin ( Prostaglandin 12 , PGI 2 ) Inhibits Platelet Adhesion and Thrombus Formation on Subendothelium
Prostaglandin I2 (prostacyclin, PGI2), a subadhesion and thrombus formation on subenstance synthesized in the wall of blood dothelium was inhibited in blood containing vessels, has been previously shown to inhibit 10 nM PGI2. PGI2 appears to reduce adhesion the aggregation of platelets in Stirred plateby inhibiting platelet spreading. These findlet-rich plasma. We used a method in which ings su...
متن کاملProstacyclin (prostaglandin I2, PGI2) inhibits platelet adhesion and thrombus formation on subendothelium.
Prostaglandin I2 (prostacyclin, PGI2), a substance synthesized in the wall of blood vessels, has been previously shown to inhibit the aggregation of platelets in stirred platelet-rich plasma. We used a method in which segments of deendothelialized rabbit aorta are perfused at arterial shear rates with human blood and found that both platelet adhesion and thrombus formation on subendothelium was...
متن کاملThrombogenic effect of high-dose aspirin in rabbits. Relationship to inhibition of vessel wall synthesis of prostaglandin I2-like activity.
Aspirin is a promising antithrombogenic agent. It inhibits the generation of thromboxane A(2) by acetylating platelet cyclo-oxygenase. Aspirin also inhibits vessel wall production of PGI(2) which is an inhibitor of platelet aggregation, and therefore is potentially thrombotic. To investigate these two opposing effects we studied the effects of aspirin upon fibrin accretion onto experimentally i...
متن کاملProstacyclin: An Inflammatory Paradox
Prostacyclin (PGI(2)) is a member of the prostaglandin family of bioactive lipids. Its best-characterized role is in the cardiovascular system, where it is released by vascular endothelial cells, serving as a potent vasodilator and inhibitor of platelet aggregation. In recent years, prostacyclin (PGI(2)) has also been shown to promote differentiation and inhibit proliferation in vascular smooth...
متن کاملThe prostaglandin E2 receptor EP4 is expressed by human platelets and potently inhibits platelet aggregation and thrombus formation.
OBJECTIVE Low concentrations of prostaglandin (PG) E(2) enhance platelet aggregation, whereas high concentrations inhibit it. The effects of PGE(2) are mediated through 4 G protein-coupled receptors, termed E-type prostaglindin (EP) receptor EP1, EP2, EP3, and EP4. The platelet-stimulating effect of PGE(2) has been suggested to involve EP3 receptors. Here we analyzed the receptor usage relating...
متن کامل